Combining Organocatalyzed Aldolization and Reductive Amination: An Efficient Reaction Sequence for the Synthesis of Iminosugars

Over the past two decades, organocatalytic aldol reaction emerged as a powerful method for enantioselective carbon–carbon bond formation, often offering more efficient, economical and environmentally friendly synthesis of chiral molecules. On other hand, reductive amination is one most important reactions in biologically active compounds drug candidates. Coupling these results combination that allows rapid, stereoselective access to substituted, highly functionalized five- six-membered N-heterocycles. This minireview illustrates applicability this approach key feature syntheses various iminosugars – class polyhydroxylated alkaloids with range interesting biological activities high pharmacological potential.